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Article

Interference with Gsα-Coupled Receptor Signaling in Renin-Producing Cells Leads to Renal Endothelial Damage.

Journal of the American Society of Nephrology : JASN - 1 Dec 2017

Lachmann Peter, Hickmann Linda, Steglich Anne, Al-Mekhlafi Moath, Gerlach Michael, Jetschin Niels, Jahn Steffen, Hamann Brigitte, Wnuk Monika, Madsen Kirsten, Djonov Valentin, Chen Min, Weinstein Lee S, Hohenstein Bernd, Hugo Christian P M, Todorov Vladimir T

Abstract excerpt

Intracellular cAMP, the production of which is catalyzed by the α-subunit of the stimulatory G protein (Gsα), controls renin synthesis and release by juxtaglomerular (JG) cells of the kidney, but may also have relevance for the physiologic integrity of the kidney. To investigate this possibility, we generated mice with inducible knockout of Gsα in JG cells and monitored them for 6 months after induction at 6...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28775003
DOI: 10.1681/ASN.2017020173
PMCID: PMC5698073

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