Article
Association study of GABRG2 polymorphisms with suicidal behaviour in schizophrenia patients with alcohol use disorder.
Neuropsychobiology - 1 Jan 2014
Zai Clement C, Zai Gwyneth C, Tiwari Arun K, Manchia Mirko, de Luca Vincenzo, Shaikh Sajid A, Strauss John, Kennedy James L
Abstract excerpt
BACKGROUND: Schizophrenia is a severe neuropsychiatric disorder where the role of γ-aminobutyric acid (GABA), an inhibitory neurotransmitter, has been implicated in its aetiopathophysiology. Several genes coding for GABAA subunits, including the GABRG2 gene that encodes the γ2 subunit, are clustered at 5q31-q35, a chromosomal region that is associated with schizophrenia in genome scan studies. We recently...
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