Article
Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes.
Clinical and experimental immunology - 1 Sept 2014
Thompson W S, Pekalski M L, Simons H Z, Smyth D J, Castro-Dopico X, Guo H, Guy C, Dunger D B, Arif S, Peakman M, Wallace C, Wicker L S, Todd J A, Ferreira R C
Abstract excerpt
The appearance of circulating islet-specific autoantibodies before disease diagnosis is a hallmark of human type 1 diabetes (T1D), and suggests a role for B cells in the pathogenesis of the disease. Alterations in the peripheral B cell compartment have been reported in T1D patients; however, to date, such studies have produced conflicting results and have been limited by sample size. In this study, we have...
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