Article
Deep Phenotyping of CD11c+ B Cells in Systemic Autoimmunity and Controls.
Frontiers in immunology - 1 Jan 2021
Rincon-Arevalo Hector, Wiedemann Annika, Stefanski Ana-Luisa, Lettau Marie, Szelinski Franziska, Fuchs Sebastian, Frei Andreas Philipp, Steinberg Malte, Kam-Thong Tony, Hatje Klas, Keller Baerbel, Warnatz Klaus, Radbruch Andreas, Lino Andreia C, Schrezenmeier Eva, Dörner Thomas
Abstract excerpt
Circulating CD11c+ B cells are a key phenomenon in certain types of autoimmunity but have also been described in the context of regular immune responses (i.e., infections, vaccination). Using mass cytometry to profile 46 different markers on individual immune cells, we systematically initially confirmed the presence of increased CD11c+ B cells in the blood of systemic lupus erythematosus (SLE) patients. Notably,...
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