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Article

Progranulin protein levels are differently regulated in plasma and CSF.

Neurology - 27 May 2014

Nicholson Alexandra M, Finch NiCole A, Thomas Colleen S, Wojtas Aleksandra, Rutherford Nicola J, Mielke Michelle M, Roberts Rosebud O, Boeve Bradley F, Knopman David S, Petersen Ronald C, Rademakers Rosa

Abstract excerpt

OBJECTIVE: We aimed to investigate the relationship between plasma and CSF progranulin (PGRN) levels. METHODS: Plasma and CSF PGRN were measured in a cohort of 345 subjects from the Mayo Clinic Study of Aging by ELISA. Single nucleotide polymorphism genotyping was performed using TaqMan assays. Associations between PGRN and sex, age at sample collection, diagnosis, single nucleotide polymorphism genotypes (GRN,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24771538
DOI: 10.1212/WNL.0000000000000445
PMCID: PMC4105255

Genes

GRN
SORT1
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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