Prosaposin is a regulator of progranulin levels and oligomerization.

doi:10.1038/ncomms11992

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Article

Prosaposin is a regulator of progranulin levels and oligomerization.

Nature communications - 30 Jun 2016

Nicholson Alexandra M, Finch NiCole A, Almeida Marcio, Perkerson Ralph B, van Blitterswijk Marka, Wojtas Aleksandra, Cenik Basar, Rotondo Sergio, Inskeep Venette, Almasy Laura, Dyer Thomas, Peralta Juan, Jun Goo, Wood Andrew R, Frayling Timothy M, Fuchsberger Christian, Fowler Sharon, Teslovich Tanya M, Manning Alisa K, Kumar Satish, Curran Joanne, Lehman Donna, Abecasis Goncalo, Duggirala Ravindranath, Pottier Cyril, Zahir Haaris A, Crook Julia E, Karydas Anna, Mitic Laura, Sun Ying, Dickson Dennis W, Bu Guojun, Herz Joachim, Yu Gang, Miller Bruce L, Ferguson Shawn, Petersen Ronald C, Graff-Radford Neill, Blangero John, Rademakers Rosa

Abstract excerpt

Progranulin (GRN) loss-of-function mutations leading to progranulin protein (PGRN) haploinsufficiency are prevalent genetic causes of frontotemporal dementia. Reports also indicated PGRN-mediated neuroprotection in models of Alzheimer's and Parkinson's disease; thus, increasing PGRN levels is a promising therapeutic for multiple disorders. To uncover novel PGRN regulators, we linked whole-genome sequence data...

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Identifiers

PMID: 27356620
DOI: 10.1038/ncomms11992
PMCID: PMC4931318

Genes

PSAP
GRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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