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Article

Dependence of antibody gene diversification on uracil excision.

The Journal of experimental medicine - 24 Dec 2007

Di Noia Javier M, Williams Gareth T, Chan Denice T Y, Buerstedde Jean-Marie, Baldwin Geoff S, Neuberger Michael S

Abstract excerpt

Activation-induced deaminase (AID) catalyses deamination of deoxycytidine to deoxyuridine within immunoglobulin loci, triggering pathways of antibody diversification that are largely dependent on uracil-DNA glycosylase (uracil-N-glycolase [UNG]). Surprisingly efficient class switch recombination is restored to ung(-/-) B cells through retroviral delivery of active-site mutants of UNG, stimulating discussion about...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18070939
DOI: 10.1084/jem.20071768
PMCID: PMC2150978

Genes

UNG
MSH2
SMUG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Dependence of antibody gene diversification on uracil excision.PMID 18070939Read ↗

Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation.Semantic proximity Read ↗

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UNG shapes the specificity of AID-induced somatic hypermutation.Semantic proximity Read ↗

Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AIDSemantic proximity Read ↗

The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice.Semantic proximity Read ↗

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation.Semantic proximity Read ↗

Molecular mechanisms of antibody somatic hypermutation.Semantic proximity Read ↗

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Balancing AID and DNA repair during somatic hypermutation.Semantic proximity Read ↗

AID in antibody perfection.Semantic proximity Read ↗

Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes.Semantic proximity Read ↗

Interplay between Target Sequences and Repair Pathways Determines Distinct Outcomes of AID-Initiated Lesions.Semantic proximity Read ↗

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