Article
Relevance of DNA repair gene polymorphisms to gastric cancer risk and phenotype.
Oncotarget - 30 May 2017
Carrera-Lasfuentes Patricia, Lanas Angel, Bujanda Luis, Strunk Mark, Quintero Enrique, Santolaria Santos, Benito Rafael, Sopeña Federico, Piazuelo Elena, Thomson Concha, Pérez-Aisa Angeles, Nicolás-Pérez David, Hijona Elizabeth, Espinel Jesús, Campo Rafael, Manzano Marisa, Geijo Fernando, Pellise María, Zaballa Manuel, González-Huix Ferrán, Espinós Jorge, Titó Llúcia, Barranco Luis, D'Amato Mauro, García-González María Asunción
Abstract excerpt
Variations in DNA repair genes have been reported as key factors in gastric cancer (GC) susceptibility but results among studies are inconsistent. We aimed to assess the relevance of DNA repair gene polymorphisms and environmental factors to GC risk and phenotype in a Caucasian population in Spain. Genomic DNA from 603 patients with primary GC and 603 healthy controls was typed for 123 single nucleotide...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Case-Control Studies
- Combined Modality Therapy
- DNA Repair
- Female
- Gene Frequency