Prognostic significance of excision repair cross complementation group 1 rs2298881 in patients with gastric cancer receiving platinum-based chemotherapy: A PRISMA-compliant meta-analysis.

doi:10.1097/MD.0000000000026850

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Prognostic significance of excision repair cross complementation group 1 rs2298881 in patients with gastric cancer receiving platinum-based chemotherapy: A PRISMA-compliant meta-analysis.

Medicine - 20 Aug 2021

Lv Yalei, Xu Mengyuan, Sun Yidan, Liu Yezhou, Zhao Lijuan, Liu Xuehui, Li Zixuan, Shi Gaiping, Jia Jinhai, Bi Lanfei, Ma Ning, Zhang Xiaolin, Qi Cheng

Abstract excerpt

BACKGROUND: Gastric cancer (GC) is a strong cause of global cancer mortality. Nucleotide excision repair (NER) can modulate platinum-based chemotherapeutic efficacy by removing drug-produced DNA damage. Some studies have found a link between excision repair cross complementation group 1 (ERCC1) rs2298881, one gene in NER pathway, and response to chemotherapy. However, the results have been disputed. METHODS: We...

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PMID: 34414935
DOI: 10.1097/MD.0000000000026850
PMCID: PMC8376342

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