Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Two-drug Model for Etoposide Action against Human Topoisomerase IIα

1 Feb 2003

Abstract excerpt

The widely used anticancer drug etoposide kills cells by increasing levels of topoisomerase II-mediated DNA breaks. While it is known that the drug acts by inhibiting the ability of topoisomerase II to ligate cleaved DNA molecules, the precise mechanism by which it accomplishes this action is not well understood. Because there are two scissile bonds per enzyme-mediated double-stranded DNA break, it has been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to Lung Cancer Research Studies
Share to Polyomavirus and related diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12473657
DOI: 10.1074/jbc.m212056200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Two-drug Model for Etoposide Action against Human Topoisomerase IIαPMID 12473657Read ↗

Etoposide, Topoisomerase II and CancerSemantic proximity Read ↗

Etoposide Quinone Is a Redox-Dependent Topoisomerase II PoisonSemantic proximity Read ↗

Etoposide Quinone Is a Covalent Poison of Human Topoisomerase IIβSemantic proximity Read ↗

Etoposide: Discovery and Medicinal ChemistrySemantic proximity Read ↗

Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide.Semantic proximity Read ↗

Etoposide promotes DNA loop trapping and barrier formation by topoisomerase IISemantic proximity Read ↗

Mechanism of action of DNA topoisomerase inhibitorsSemantic proximity Read ↗

Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanismsSemantic proximity Read ↗

Topoisomerase II and leukemiaSemantic proximity Read ↗

Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase IISemantic proximity Read ↗

The Efficacy of Topoisomerase II-Targeted Anticancer Agents Reflects the Persistence of Drug-Induced Cleavage Complexes in CellsSemantic proximity Read ↗

DNA Topoisomerases as Targets for the Anticancer Drug TAS-103: Primary Cellular Target and DNA Cleavage EnhancementSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.