Article
[Correlation analysis of FPGS rs10760502G>a polymorphism with prognosis and MTX-related toxicity in pediatric B-cell acute lymphoblastic leukemia].
Zhongguo shi yan xue ye xue za zhi - 1 Apr 2014
Liu Shu-Guang, Gao Chao, Li Zhi-Gang, Li Wei-Jing, Cui Lei, Zhao Xiao-Xi, Zheng Hu-Yong, Wu Min-Yuan, Zhang Rui-Dong
Abstract excerpt
This study was aimed to explore the relation between folylpolyglutamate synthetase (FPGS) rs10760502 polymorphism and prognosis and methotrexate (MTX)-related toxicities in pediatric B-cell acute lymphoblastic leukemia (B-ALL). Sequenom MassARRAY was used to genotype rs10760502. The χ(2) test, Kaplan-Meier method and Cox regression models were used to analyze the data. The results indicated that A allele carriers...
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