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Article

Frequency distribution of five SNPs in human GGH gene and their effects on clinical outcomes of Chinese pediatric patients with acute lymphoblastic leukemia.

Die Pharmazie - 6 Apr 2020

Li Miao, Wang Shu-Mei, Wu Wan-Shui, Yan Dan, Zhang Le-Ping, Zheng Hu-Yong

Abstract excerpt

Methotrexate (MTX) is widely used in the treatment of childhood acute lymphoblastic leukemia (ALL). Gamma-glutamyl hydrolase (GGH) plays an important role in the disposition of MTX. The aim of this study was to investigate the frequency distribution of five SNPs in the human GGH gene and their effects on serum MTX concentrations and clinical outcomes in Chinese children with ALL. Genotyping of 149 pediatric...

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Identifiers

PMID: 32295690
DOI: 10.1691/ph.2020.9932

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