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Article

Effect of the Polymorphism of Folylpolyglutamate Synthetase on Treatment of High-Dose Methotrexate in Pediatric Patients with Acute Lymphocytic Leukemia.

Medical science monitor : international medical journal of experimental and clinical research - 17 Dec 2016

Huang Zhen, Tong Hong-Fei, Li Yuan, Qian Jiang-Chao, Wang Ju-Xiang, Wang Zhe, Ruan Ji-Chen

Abstract excerpt

BACKGROUND The aim of this study was to investigate the association of the polymorphism of folylpolyglutamate synthetase (FPGS) with the dynamic plasma concentration of methotrexate (MTX) in pediatric patients with acute lymphocytic leukemia (ALL), as well as the prognosis. MATERIAL AND METHODS 57 ALL patients and 31 age and sex-matched children (control) were included in this study. Polymerase chain...

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Identifiers

PMID: 27987364
DOI: 10.12659/msm.899021
PMCID: PMC5189722

Genes

FPGS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effect of the Polymorphism of Folylpolyglutamate Synthetase on Treatment of High-Dose Methotrexate in Pediatric Patients with Acute Lymphocytic Leukemia.PMID 27987364Read ↗

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Modeling Mechanisms of In Vivo Variability in Methotrexate Accumulation and Folate Pathway Inhibition in Acute Lymphoblastic Leukemia CellsSemantic proximity Read ↗

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