Article
Mutation Screening and Association Study of the Folylpolyglutamate Synthetase (FPGS) Gene with Susceptibility to Childhood Acute Lymphoblastic Leukemia.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2015
Piwkham Duangjai, Siriboonpiputtana Teerapong, Beuten Joke, Pakakasama Samart, Gelfond Jonathan Al, Paisooksantivatana Karan, Tomlinson Gail E, Rerkamnuaychoke Budsaba
Abstract excerpt
BACKGROUND: Folylpolyglutamate synthetase (FPGS), an important enzyme in the folate metabolic pathway, plays a central role in intracellular accumulation of folate and antifolate in several mammalian cell types. Loss of FPGS activity results in decreased cellular levels of antifolates and consequently to polyglutamatable antifolates in acute lymphoblastic leukemia (ALL). MATERIALS AND METHODS: During May 1997 and...
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