Influence of genetic polymorphisms of FPGS, GGH, and MTHFR on serum methotrexate levels in Chinese children with acute lymphoblastic leukemia.

doi:10.1007/s00280-014-2507-8

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Influence of genetic polymorphisms of FPGS, GGH, and MTHFR on serum methotrexate levels in Chinese children with acute lymphoblastic leukemia.

Cancer chemotherapy and pharmacology - 1 Aug 2014

Wang Shu-mei, Sun Lu-lu, Zeng Wei-xin, Wu Wan-shui, Zhang Guo-liang

Abstract excerpt

PURPOSE: To investigate the correlation between common genetic polymorphisms of folylpolyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), and methylenetetrahydrofolate reductase (MTHFR) and serum levels of methotrexate (MTX) in Chinese children with acute lymphoblastic leukemia (ALL). METHODS: Ninety-one children with ALL who received high-dose MTX were recruited. The polymorphisms FPGS (rs1544105 G>A),...

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PMID: 24908438
DOI: 10.1007/s00280-014-2507-8

Genes

GGH
FPGS
MTHFR

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