Article
[A novel missense mutation of folypolyglutamate synthetase gene].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics - 1 Jul 2012
Hu Chun-Yan, Yue Li-Jie, Yu Jie, Zhang Hong-Hong, Yang Chun-Lan
Abstract excerpt
OBJECTIVE: To examine allelic frequencies of coding single nucleotide polymorphisms (cSNPs) of folypolyglutamate synthetase (FPGS) gene in Chinese Han children with acute leukemia (AL), in order to provide a basis for detecting the relationship between FPGS genetic polymorphisms and tumor individualized chemotherapy. METHODS: cSNPs of exon 5 were detected with polymerase chain reaction (PCR)-denaturing gradient...
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