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Article

Constitutional promoter methylation and risk of familial melanoma.

Epigenetics - 1 May 2014

Hyland Paula L, Burke Laura S, Pfeiffer Ruth M, Rotunno Melissa, Sun David, Patil Prasad, Wu Xiaolin, Tucker Margaret A, Goldstein Alisa M, Yang Xiaohong Rose

Abstract excerpt

Constitutional epigenetic changes detected in blood or non-disease involving tissues have been associated with disease susceptibility. We measured promoter methylation of CDKN2A (p16 and p14ARF) and 13 melanoma-related genes using bisulfite pyrosequencing of blood DNA from 114 cases and 122 controls in 64 melanoma-prone families (26 segregating CDKN2A germline mutations). We also obtained gene expression data for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24762620
DOI: 10.4161/epi.28151
PMCID: PMC4063827

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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