Article
Identification of modifier genes for cutaneous malignant melanoma in melanoma-prone families with and without CDKN2A mutations.
International journal of cancer - 15 Dec 2009
Yang Xiaohong Rose, Pfeiffer Ruth M, Wheeler William, Yeager Meredith, Chanock Stephen, Tucker Margaret A, Goldstein Alisa M
Abstract excerpt
CDKN2A is a major susceptibility gene for cutaneous malignant melanoma (CMM), but the variable penetrance and clinical manifestations among mutation carriers suggest the existence of modifier factors. The goal of this study was to identify modifier genes for CMM in CMM-prone families with or without CDKN2A mutations. We genotyped 537 individuals (107 CMM) from 28 families (19 CDKN2A+, 9 CDKN2A-) for 1,536 SNPs in...
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