Article
Genome-wide DNA methylation profile of leukocytes from melanoma patients with and without CDKN2A mutations.
Experimental and molecular pathology - 1 Dec 2014
de Araújo Érica Sara Souza, Marchi Fabio Albuquerque, Rodrigues Tatiane Cristina, Vieira Henrique Cursino, Kuasne Hellen, Achatz Maria Isabel Waddington, Moredo Luciana Facure, de Sá Bianca Costa Soares, Duprat João Pereira, Brentani Helena Paula, Rosenberg Carla, Carraro Dirce Maria, Krepischi Ana Cristina Victorino
Abstract excerpt
Melanoma is a highly aggressive cancer, accounting for up to 75% of skin cancer deaths. A small proportion of melanoma cases can be ascribed to the presence of highly penetrant germline mutations, and approximately 40% of hereditary melanoma cases are caused by CDKN2A mutations. The current study sought to investigate whether the presence of germline CDKN2A mutations or the occurrence of cutaneous melanoma would...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.