Article
DNA methylation variations of DNA damage response correlate survival and local immune status in melanomas.
Immunity, inflammation and disease - 1 Sept 2024
Wang Min, Zhang Xiao-Dong, Yang Han-Qing, Li Yang, Chen Wen-Mei, Yin An-An
Abstract excerpt
AIM: We aimed to explore the impact of DNA methylation alterations on the DNA damage response (DDR) in melanoma prognosis and immunity. MATERIAL & METHODS: Different melanoma cohorts with molecular and clinical data were included. RESULTS: Hierarchical clustering utilizing different combinations of DDR-relevant CpGs yielded distinct melanoma subtypes, which were characteristic of different prognoses,...
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