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Article

Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention.

Oncotarget - 1 Jan 2013

Fan Meiyun, Pfeffer Susan R, Lynch Henry T, Cassidy Pamela, Leachman Sancy, Pfeffer Lawrence M, Kopelovich Levy

Abstract excerpt

Familial melanoma (FM) is a dominantly heritable cancer that is associated with mutations in the tumor suppressor CDKN2A/p16. In FM, a single inherited "hit" occurs in every somatic cell, enabling interrogation of cultured normal skin fibroblasts (SFs) from FM gene carriers as surrogates for the...

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Identifiers

PMID: 23371019
DOI: 10.18632/oncotarget.786
PMCID: PMC3702213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23371019-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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