Article
LINE-1 methylation in peripheral blood and the risk of melanoma in melanoma-prone families with and without CDKN2A mutations.
Melanoma research - 1 Feb 2013
Hyland Paula L, Burke Laura S, Pfeiffer Ruth M, Mirabello Lisa, Tucker Margaret A, Goldstein Alisa M, Yang Xiaohong R
Abstract excerpt
Cutaneous malignant melanoma (CMM) is an etiologically heterogenous disease with genetic, environmental (sun exposure), and host (pigmentation/nevi) factors and their interactions contributing to risk. Recently, epigenetic changes involving reduced levels of global DNA methylation in blood have been associated with genomic instability and cancer risk. We thus examined whether global methylation was associated...
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