Article
Transcription of methylated viral DNA by eukaryotic RNA polymerase II.
Cell biophysics - 1 Jan 2000
Willis D B, Thompson J P, Essani K, Goorha R
Abstract excerpt
The genome of the large icosahedral DNA virus, frog virus 3 (FV3), is heavily methylated at the cytosine residues of dCdG dinucleotide pairs, with more than 22% of the total cytosine residues in the form of 5-methylcytosine (5mC). This methylation is carried out postreplicatively in the cytoplasm of infected cells by a virus-encoded DNA methyltransferase. DNA methyltransferase activity was shown to copurify with...
Topics
- Animals
- Base Sequence
- Cell Line
- Cricetinae
- DNA Modification Methylases
- DNA, Viral
- DNA-Binding Proteins
- HeLa Cells
- Humans
- Iridoviridae
- Methylation
- Mutation