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Histone H3 Lysine 4 Methylation Marks Postreplicative Human Cytomegalovirus Chromatin

4 Jul 2012

Abstract excerpt

In the nuclei of permissive cells, human cytomegalovirus genomes form nucleosomal structures initially resembling heterochromatin but gradually switching to a euchromatin-like state. This switch is characterized by a decrease in histone H3 K9 methylation and a marked increase in H3 tail acetylation and H3 K4 methylation across the viral genome. We used ganciclovir and a mutant virus encoding a reversibly...

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PMID: 22761369
DOI: 10.1128/jvi.00581-12

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