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Article

Valence-specific effects of BDNF Val66Met polymorphism on dopaminergic stress and reward processing in humans.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Apr 2014

Peciña Marta, Martínez-Jauand Mercedes, Love Tiffany, Heffernan Joseph, Montoya Pedro, Hodgkinson Colin, Stohler Christian S, Goldman David, Zubieta Jon-Kar

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) levels in dopaminergic (DA) cells within the ventral tegmental area (VTA)/nucleus accumbens (NAc) circuitry appear to be a candidate mechanism for the neuroadaptive changes that follow stress and reward responses in animal models. However, the role of the BDNF gene variants in responses to salient cues through DA neurotransmission in humans remains unexplored. Here, we...

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Identifiers

PMID: 24760847
DOI: 10.1523/JNEUROSCI.2152-13.2014
PMCID: PMC3996214

Genes

BDNF

Variants

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