Article
Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis.
Genome research - 1 May 2014
Holstege Henne, Pfeiffer Wayne, Sie Daoud, Hulsman Marc, Nicholas Thomas J, Lee Clarence C, Ross Tristen, Lin Jue, Miller Mark A, Ylstra Bauke, Meijers-Heijboer Hanne, Brugman Martijn H, Staal Frank J T, Holstege Gert, Reinders Marcel J T, Harkins Timothy T, Levy Samuel, Sistermans Erik A
Abstract excerpt
The somatic mutation burden in healthy white blood cells (WBCs) is not well known. Based on deep whole-genome sequencing, we estimate that approximately 450 somatic mutations accumulated in the nonrepetitive genome within the healthy blood compartment of a 115-yr-old woman. The detected mutations appear to have been harmless passenger mutations: They were enriched in noncoding, AT-rich regions that are not...
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