Article
The screening of the 3'UTR sequence of LRRK2 identified an association between the rs66737902 polymorphism and Parkinson's disease.
Journal of human genetics - 1 Jun 2014
Cardo Lucía F, Coto Eliecer, Ribacoba René, Mata Ignacio F, Moris Germán, Menéndez Manuel, Alvarez Victoria
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are the most common genetic determinants of familial and sporadic Parkinson's disease (PD). Most of the mutational screenings analyzed the exon-coding sequence. Our aim was to determine whether LRRK2 3' untranslated region (UTR) variants were associated with the risk of developing PD in a large cohort of patients (n=743) and controls (n=523) from Spain....
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