GRN 3'UTR+78 C>T is not associated with risk for Parkinson's disease.

doi:10.1111/j.1468-1331.2009.02621.x

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Article

GRN 3'UTR+78 C>T is not associated with risk for Parkinson's disease.

European journal of neurology - 1 Aug 2009

Jasinska-Myga B, Wider C, Opala G, Krygowska-Wajs A, Barcikowska M, Czyzewski K, Baker M, Rademakers R, Uitti R J, Farrer M J, Ross O A, Wszolek Z K

Abstract excerpt

BACKGROUND AND PURPOSE: A single nucleotide polymorphism in the 3'-untranslated region of the progranulin gene (GRN; 3'UTR+78C>T; rs5848) was reported to alter the risk for frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). rs5848 is located within a micro-RNA binding site and affects the expression of GRN. METHODS: As FTLD-U patients often present with parkinsonism, we investigated...

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PMID: 19473366
DOI: 10.1111/j.1468-1331.2009.02621.x

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GRN 3'UTR+78 C>T is not associated with risk for Parkinson's disease.PMID 19473366Read ↗

Variation at GRN 3'-UTR rs5848 is not associated with a risk of frontotemporal lobar degeneration in Dutch population.Semantic proximity Read ↗

No association of PGRN 3'UTR rs5848 in frontotemporal lobar degeneration.Semantic proximity Read ↗

Rs5848 variant influences GRN mRNA levels in brain and peripheral mononuclear cells in patients with Alzheimer's disease.Semantic proximity Read ↗

The screening of the 3'UTR sequence of LRRK2 identified an association between the rs66737902 polymorphism and Parkinson's disease.Semantic proximity Read ↗

Common variant in GRN is a genetic risk factor for hippocampal sclerosis in the elderly.Semantic proximity Read ↗

Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia.Semantic proximity Read ↗

A mutation in the 5'-UTR of GRN gene associated with frontotemporal lobar degeneration: phenotypic variability and possible pathogenetic mechanisms.Semantic proximity Read ↗

GRN variability contributes to sporadic frontotemporal lobar degeneration.Semantic proximity Read ↗

Association between GRN rs5848 polymorphism and Parkinson's disease in Taiwanese population.Semantic proximity Read ↗

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Association of progranulin polymorphism rs5848 with neurodegenerative diseases: a meta-analysis.Semantic proximity Read ↗

Reduced serum progranulin level might be associated with Parkinson's disease risk.Semantic proximity Read ↗

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