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Article

Hypermutable DNA chronicles the evolution of human colon cancer.

Proceedings of the National Academy of Sciences of the United States of America - 6 May 2014

Naxerova Kamila, Brachtel Elena, Salk Jesse J, Seese Aaron M, Power Karen, Abbasi Bardia, Snuderl Matija, Chiang Sarah, Kasif Simon, Jain Rakesh K

Abstract excerpt

Intratumor genetic heterogeneity reflects the evolutionary history of a cancer and is thought to influence treatment outcomes. Here we report that a simple PCR-based assay interrogating somatic variation in hypermutable polyguanine (poly-G) repeats can provide a rapid and reliable assessment of mitotic history and clonal architecture in human cancer. We use poly-G repeat genotyping to study the evolution of colon...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24753616
DOI: 10.1073/pnas.1400179111
PMCID: PMC4020055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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