Article
MicroRNA-31 expression in relation to BRAF mutation, CpG island methylation and colorectal continuum in serrated lesions.
International journal of cancer - 1 Dec 2014
Ito Miki, Mitsuhashi Kei, Igarashi Hisayoshi, Nosho Katsuhiko, Naito Takafumi, Yoshii Shinji, Takahashi Hiroaki, Fujita Masahiro, Sukawa Yasutaka, Yamamoto Eiichiro, Takahashi Taiga, Adachi Yasushi, Nojima Masanori, Sasaki Yasushi, Tokino Takashi, Baba Yoshifumi, Maruyama Reo, Suzuki Hiromu, Imai Kohzoh, Yamamoto Hiroyuki, Shinomura Yasuhisa
Abstract excerpt
The CpG island methylator phenotype (CIMP) is a distinct form of epigenomic instability. Many CIMP-high colorectal cancers (CRCs) with BRAF mutation are considered to arise from serrated pathway. We recently reported that microRNA-31 (miR-31) is associated with BRAF mutation in colorectal tumors. Emerging new approaches have revealed gradual changes in BRAF mutation and CIMP-high throughout the colorectum in...
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