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Article

Novel nikkomycin analogues generated by mutasynthesis in Streptomyces ansochromogenes.

Microbial cell factories - 21 Apr 2014

Feng Chi, Ling Hongbo, Du Deyao, Zhang Jihui, Niu Guoqing, Tan Huarong

Abstract excerpt

BACKGROUND: Nikkomycins are competitive inhibitors of chitin synthase and inhibit the growth of filamentous fungi, insects, acarids and yeasts. The gene cluster responsible for biosynthesis of nikkomycins has been cloned and the biosynthetic pathway was elucidated at the genetic, enzymatic and regulatory levels. RESULTS: Streptomyces ansochromogenes ΔsanL was constructed by homologous recombination and the mutant...

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Identifiers

PMID: 24751325
DOI: 10.1186/1475-2859-13-59
PMCID: PMC4021061

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Novel nikkomycin analogues generated by mutasynthesis in Streptomyces ansochromogenes.PMID 24751325Read ↗

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