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Article

Production of nikkomycins Bx and Bz by mutasynthesis with genetically engineered Streptomyces tendae Tü901.

The Journal of antibiotics - 1 Feb 1999

Bormann C, Kálmánczhelyi A, Süssmuth R, Jung G

Abstract excerpt

The previously described Streptomyces tendae nikC::aph mutant was used to mutasynthesize nikkomycins Bx and Bz. The mutant is deficient in L-lysine 2-aminotransferase, which transaminates lysine to form piperideine 2-carboxylate, the precursor of the peptidyl side chain of the biologically active nikkomycins I, J, X, and Z, and is therefore unable to produce these nikkomycins. The mutant accumulates the...

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PMID: 10344563
DOI: 10.7164/antibiotics.52.102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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