Nikkomycin Z is a specific inhibitor of Saccharomyces cerevisiae chitin synthase isozyme Chs3 in vitro and in vivo.

doi:10.1128/jb.176.18.5857-5860.1994

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Article

Nikkomycin Z is a specific inhibitor of Saccharomyces cerevisiae chitin synthase isozyme Chs3 in vitro and in vivo.

Journal of bacteriology - 1 Sept 1994

Gaughran J P, Lai M H, Kirsch D R, Silverman S J

Abstract excerpt

Nikkomycin Z inhibits chitin synthase in vitro but does not exhibit antifungal activity against many pathogens. Assays of chitin synthase isozymes and growth assays with isozyme mutants were used to demonstrate that nikkomycin Z is a selective inhibitor of chitin synthase 3. The resistance of chi...

Topics

Aminoglycosides
Anti-Bacterial Agents
Antifungal Agents
Benzenesulfonates
Chitin Synthase
Drug Resistance, Microbial
Fluorescent Dyes
Isoenzymes
Kinetics
Mutation
Pyrimidine Nucleosides
Saccharomyces cerevisiae

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