Article
Disruption of sabR affects nikkomycin biosynthesis and morphogenesis in Streptomyces ansochromogenes.
Biotechnology letters - 1 Sept 2003
Li Wenli, Liu Gang, Tan Huarong
Abstract excerpt
The gene, sabR, encoding a receptor for gamma-butyrolactone, was cloned from the genomic DNA of Streptomyces ansochromogenes 7100. Its deduced protein shows strong homology to several gamma-butyrolactone-binding proteins in Streptomyces. Disruption of sabR retarded nikkomycin production in liquid media containing glucose or glycerol as carbon source. Sporulation of sabR disruption mutants was earlier than the...
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