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Article

Identification and characterization of sanH and sanI involved in the hydroxylation of pyridyl residue during nikkomycin biosynthesis in Streptomyces ansochromogenes.

Current microbiology - 1 Dec 2007

Xie Zhoujie, Niu Guoqing, Li Rui, Liu Gang, Tan Huarong

Abstract excerpt

Nikkomycins are highly potent inhibitors of chitin synthase. The nikkomycin biosynthetic gene cluster has been cloned from Streptomyces asochromogenes. Two cytochrome P450 monooxygenase genes (sanQ, sanH) and one ferredoxin gene (sanI) were found in the cluster. It was reported that SanQ is involved in the hydroxylation of L-His, a key step in 4-formyl-4-imidazolin-2-one base biosynthesis. Here, we have studied...

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PMID: 17899263
DOI: 10.1007/s00284-007-9028-1

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Identification and characterization of sanH and sanI involved in the hydroxylation of pyridyl residue during nikkomycin biosynthesis in Streptomyces ansochromogenes.PMID 17899263Read ↗

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