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Article

Sexually dimorphic effect of catechol-O-methyltransferase val158met polymorphism on clinical response to fluoxetine in major depressive patients.

Journal of affective disorders - 1 Feb 2009

Tsai Shih-Jen, Gau Yung-Tian A, Hong Chen-Jee, Liou Ying-Jay, Yu Younger W-Y, Chen Tai-Jui

Abstract excerpt

BACKGROUND: Essential in dopamine degradation, it was suggested that catechol-O-methyltransferase (COMT) might be involved in the action of antidepressants and may therefore be a promising candidate for antidepressant pharmacogenetic studies. METHODS: COMT Val158met polymorphism was genotyped in 334 Chinese major depressive disorder (MDD) patients who were treated with fluoxetine for at least 4 weeks. Clinical...

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Source

Identifiers

PMID: 18533273
DOI: 10.1016/j.jad.2008.04.017

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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