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Article

Sporadic Inclusion Body Myositis: An Acquired Mitochondrial Disease with Extras

7 Jan 2019

Abstract excerpt

The sporadic form of inclusion body myositis (IBM) is the most common late-onset myopathy. Its complex pathogenesis includes degenerative, inflammatory and mitochondrial aspects. However, which of those mechanisms are cause and which effect, as well as their interrelations, remain partly obscured to this day. In this review the nature of the mitochondrial dysregulation in IBM muscle is explored and comparison is...

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PMID: 30621041
DOI: 10.3390/biom9010015

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