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Article

A Mouse Model for the Molecular Characterization of Brca1-Associated Ovarian Carcinoma

15 Sept 2006

Abstract excerpt

Little is known about the mechanisms that underlie Brca1-associated ovarian tumorigenesis, mainly due to the lack of an appropriate experimental model. We developed genetically defined primary mouse ovarian surface epithelial (OSE) cell lines in which the loss of functional Brca1 and p53 recapitulates the events that are thought to occur in early ovarian cancer development in patients with Brca1 mutations. This...

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PMID: 16982732
DOI: 10.1158/0008-5472.can-06-1495

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