Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of prolyl oligopeptidase increases the survival of alpha-synuclein overexpressing cells after rotenone exposure by reducing alpha-synuclein oligomers.

Neuroscience letters - 7 Nov 2014

Dokleja Lana, Hannula Mirva J, Myöhänen Timo T

Abstract excerpt

α-Synuclein (aSyn) aggregation, mitochondrial dysfunction and oxidative damage has been shown to be related to the death of dopaminergic neurons in Parkinson's disease (PD). Prolyl oligopeptidase (PREP) is proposed to increase aSyn aggregation, and PREP inhibition has been shown to inhibit the aggregation process in vitro and in vivo. In this study, we investigated the effects of a specific PREP inhibitor,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Autophagy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proline

Share to Protein Aggregates

Share to Rotenone

Share to Serine Endopeptidases

Share to Serine Proteinase Inhibitors

Share to Solubility

Source

Identifiers

PMID: 25240592
DOI: 10.1016/j.neulet.2014.09.026

Genes

PREP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of prolyl oligopeptidase increases the survival of alpha-synuclein overexpressing cells after rotenone exposure by reducing alpha-synuclein oligomers.PMID 25240592Read ↗

The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse.Semantic proximity Read ↗

Prolyl oligopeptidase inhibition attenuates the toxicity of a proteasomal inhibitor, lactacystin, in the alpha-synuclein overexpressing cell culture.Semantic proximity Read ↗

Combination of alpha-synuclein aggregation inhibitor anle138b and ER stress inhibitor AMG PERK 44 increases neuroprotection in Parkinson’s disease organoid modelSemantic proximity Read ↗

Proteasomal inhibition hypersensitizes differentiated neuroblastoma cells to oxidative damage.Semantic proximity Read ↗

[Cellular pathophysiology of Parkinson's disease].Semantic proximity Read ↗

Neuroprotection of α-synuclein under acute and chronic rotenone and maneb treatment is abolished by its familial Parkinson's disease mutations A30P, A53T and E46K.Semantic proximity Read ↗

Loss in Toxic Function of Aggregates of α -Synuclein Mutants by a β-Synuclein Derived Peptide.Semantic proximity Read ↗

Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models.Semantic proximity Read ↗

Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity.Semantic proximity Read ↗

Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of AutophagySemantic proximity Read ↗

Involvement of mortalin/GRP75/mthsp70 in the mitochondrial impairments induced by A53T mutant α-synuclein.Semantic proximity Read ↗

Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.