Article
Evaluating the role of mitochondrial DNA variation to the genetic predisposition to radiation-induced toxicity.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 May 2014
Fachal Laura, Mosquera-Miguel Ana, Gómez-Caamaño Antonio, Sánchez-García Manuel, Calvo Patricia, Lobato-Busto Ramón, Salas Antonio, Vega Ana
Abstract excerpt
BACKGROUND AND PURPOSE: Mitochondrial DNA common variants have been reported to be associated with the development of radiation-induced toxicity. Using a large cohort of patients, we aimed to validate these findings by investigating the potential role of common European mitochondrial DNA SNPs (mtSNPs) to the development of radio-toxicity. MATERIAL AND METHODS: Overall acute and late toxicity data were assessed in...
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