Polymorphisms in DNA-repair genes in a cohort of prostate cancer patients from different areas in Spain: heterogeneity between populations as a confounding factor in association studies.

doi:10.1371/journal.pone.0069735

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Article

Polymorphisms in DNA-repair genes in a cohort of prostate cancer patients from different areas in Spain: heterogeneity between populations as a confounding factor in association studies.

PloS one - 1 Jan 2013

Henríquez-Hernández Luis Alberto, Valenciano Almudena, Foro-Arnalot Palmira, Alvarez-Cubero María Jesús, Cozar José Manuel, Suárez-Novo José Francisco, Castells-Esteve Manel, Ayala-Gil Adriana, Fernández-Gonzalo Pablo, Ferrer Montse, Guedea Ferrán, Sancho-Pardo Gemma, Craven-Bartle Jordi, Ortiz-Gordillo María José, Cabrera-Roldán Patricia, Herrera-Ramos Estefanía, Lara Pedro C

Abstract excerpt

BACKGROUND: Differences in the distribution of genotypes between individuals of the same ethnicity are an important confounder factor commonly undervalued in typical association studies conducted in radiogenomics. OBJECTIVE: To evaluate the genotypic distribution of SNPs in a wide set of Spanish prostate cancer patients for determine the homogeneity of the population and to disclose potential bias. DESIGN SETTING...

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PMID: 23936089
DOI: 10.1371/journal.pone.0069735
PMCID: PMC3720621

Genes

ATM
ERCC1
ERCC2
LIG4
XRCC1

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