Article
Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Dec 2016
Andreassen Christian Nicolaj, Rosenstein Barry S, Kerns Sarah L, Ostrer Harry, De Ruysscher Dirk, Cesaretti Jamie A, Barnett Gillian C, Dunning Alison M, Dorling Leila, West Catharine M L, Burnet Neil G, Elliott Rebecca, Coles Charlotte, Hall Emma, Fachal Laura, Vega Ana, Gómez-Caamaño Antonio, Talbot Christopher J, Symonds R Paul, De Ruyck Kim, Thierens Hubert, Ost Piet, Chang-Claude Jenny, Seibold Petra, Popanda Odilia, Overgaard Marie, Dearnaley David, Sydes Matthew R, Azria David, Koch Christine Anne, Parliament Matthew, Blackshaw Michael, Sia Michael, Fuentes-Raspall Maria J, Ramon Y Cajal Teresa, Barnadas Agustin, Vesprini Danny, Gutiérrez-Enríquez Sara, Mollà Meritxell, Díez Orland, Yarnold John R, Overgaard Jens, Bentzen Søren M, Alsner Jan
Abstract excerpt
PURPOSE: Several small studies have indicated that the ATM rs1801516 SNP is associated with risk of normal tissue toxicity after radiotherapy. However, the findings have not been consistent. In order to test this SNP in a well-powered study, an individual patient data meta-analysis was carried out by the International Radiogenomics Consortium. MATERIALS AND METHODS: The analysis included 5456 patients from 17...
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