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Article

Mitochondrial haplogroups and polymorphisms reveal no association with sporadic prostate cancer in a southern European population.

PloS one - 1 Jan 2012

Álvarez-Cubero María Jesús, Saiz Guinaldo María, Martínez-González Luís Javier, Álvarez Merino Juan Carlos, Cózar Olmo José Manuel, Acosta José Antonio Lorente

Abstract excerpt

BACKGROUND: It is known that mitochondria play an important role in certain cancers (prostate, renal, breast, or colorectal) and coronary disease. These organelles play an essential role in apoptosis and the production of reactive oxygen species; in addition, mtDNA also reveals the history of populations and ancient human migration. All these events and variations in the mitochondrial genome are thought to cause...

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Identifiers

PMID: 22815971
DOI: 10.1371/journal.pone.0041201
PMCID: PMC3398884

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