Article
Investigation of genetic polymorphisms related to the outcome of radiotherapy for prostate cancer patients.
Disease markers - 1 Jan 2013
Cintra Hellen Silva, Pinezi Juliana Castro Dourado, Machado Graziella Dias Pinheiro, de Carvalho Gustavo Moura, Carvalho Ana Terra Silva, dos Santos Thalles Eduardo Dias, Marciano Ricardo Duarte, Soares Renata de Bastos Ascenço
Abstract excerpt
The purpose of this study was to evaluate the association between ATM, TP53 and MDM2 polymorphisms in prostate cancer patients and morbidity after radiotherapy. The presence of ATM (rs1801516), TP53 (rs1042522, rs1800371, rs17878362, rs17883323, and ), and MDM2 () polymorphisms was assessed by direct sequencing of PCR fragments from 48 patients with histologically proven prostate adenocarcinoma...