Article
Genetic variants in inducible nitric oxide synthase gene are associated with the risk of radiation-induced lung injury in lung cancer patients receiving definitive thoracic radiation.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 May 2014
Zhang Jian, Li Baosheng, Ding Xiuping, Sun Mingping, Li Hongsheng, Yang Ming, Zhou Changchun, Yu Haiying, Liu Hong, Yu Gongqi
Abstract excerpt
BACKGROUND AND PURPOSE: Nitric oxide (NO), mainly synthesized by inducible nitric oxide synthase (NOS2) in pathological conditions, plays an important role in cytotoxicity, inflammation and fibrosis. Elevations in exhaled NO after thoracic radiation have been reported to predict radiation-induced lung injury (RILI). This study examined whether genetic variations in NOS2 gene is associated with the risk of RILI....
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