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Article

SNP in TXNRD2 associated with radiation-induced fibrosis: a study of genetic variation in reactive oxygen species metabolism and signaling.

International journal of radiation oncology, biology, physics - 15 Jul 2013

Edvardsen Hege, Landmark-Høyvik Hege, Reinertsen Kristin V, Zhao Xi, Grenaker-Alnæs Grethe Irene, Nebdal Daniel, Syvänen Ann-Christine, Rødningen Olaug, Alsner Jan, Overgaard Jens, Borresen-Dale Anne-Lise, Fosså Sophie D, Kristensen Vessela N

Abstract excerpt

PURPOSE: The aim of the study was to identify noninvasive markers of treatment-induced side effects. Reactive oxygen species (ROS) are generated after irradiation, and genetic variation in genes related to ROS metabolism might influence the level of radiation-induced adverse effects (AEs). METHODS AND MATERIALS: 92 breast cancer (BC) survivors previously treated with hypofractionated radiation therapy were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23597419
DOI: 10.1016/j.ijrobp.2013.02.025

Genes

TXNRD2
APEX1
CENPE
EGFR
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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