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Article

Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1.

Cell death & disease - 17 Apr 2014

Burbulla L F, Fitzgerald J C, Stegen K, Westermeier J, Thost A-K, Kato H, Mokranjac D, Sauerwald J, Martins L M, Woitalla D, Rapaport D, Riess O, Proikas-Cezanne T, Rasse T M, Krüger R

Abstract excerpt

The mitochondrial chaperone mortalin was implicated in Parkinson's disease (PD) because of its reduced levels in the brains of PD patients and disease-associated rare genetic variants that failed to rescue impaired mitochondrial integrity in cellular knockdown models. To uncover the molecular mechanisms underlying mortalin-related neurodegeneration, we dissected the cellular surveillance mechanisms related to...

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Identifiers

PMID: 24743735
DOI: 10.1038/cddis.2014.103
PMCID: PMC4001296

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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