Article
Rad51 overexpression and resistance to genotoxic agents. A study in the fission yeast Schizosaccharomyces pombe.
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi - 1 Jan 2000
Stanescu Raluca Stefania, Bordeianu Gabriela, Stoica B, Ungureanu Didona, Rusu M, Petrescu-Danila Elena
Abstract excerpt
BACKGROUND: Many cancer cell lines have been found to overexpress the recombinase Rad51. The overexpression is associated with increased invasive potential and resistance to DNA-damaging therapeutic agents. This has been attributed to an increased capacity of cells overexpressing Rad51 to repair DNA lesions or to a genetic stabilization of the genome. AIM: As the explanations are somewhat controversial, we...
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