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Article

Expression and regulation of RAD51 mediate cellular responses to chemotherapeutics.

Biochemical pharmacology - 15 Mar 2012

Yang Zhengguan, Waldman Alan S, Wyatt Michael D

Abstract excerpt

There is evidence that RAD51 expression associates with resistance to commonly used chemotherapeutics. Our previous work demonstrated that inhibitors of thymidylate synthase (TS) induced RAD51-dependent homologous recombination (HR), and depleting the RAD51 recombinase sensitized cells to TS inhibitors. In this study, the consequences of RAD51 over-expression were studied. Over-expression of wild-type RAD51...

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Source

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Identifiers

PMID: 22222428
DOI: 10.1016/j.bcp.2011.12.022
PMCID: PMC3278513

Genes

RAD51

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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