Article
Single-nucleotide polymorphisms and genome diversity in Plasmodium vivax.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 2003
Feng Xiaorong, Carlton Jane M, Joy Deirdre A, Mu Jianbing, Furuya Tetsuya, Suh Bernard B, Wang Yufeng, Barnwell John W, Su Xin-Zhuan
Abstract excerpt
The study of genetic variation in malaria parasites has practical significance for developing strategies to control the disease. Vaccines based on highly polymorphic antigens may be confounded by allelic restriction of the host immune response. In response to drug pressure, a highly plastic genome may generate resistant mutants more easily than a monomorphic one. Additionally, the study of the distribution of...
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